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PLANT EXTRACT

 

 

Magnolol                     

 

Plant original:Magnolia officinalis.
Part used: Bark
Active ingredient: Magnolol, Honokiol
CAS No.: Magnolol (528-43-8)

Molecular formula: C18H18O2
Molecular weight: 266.334g/mol
Molecular structure:

Specification  Magnolol >98% White crystalline powder


Function

1. Honokiol has been used in the traditional Japanese medicine as an anxiolytic,anti-thrombotic, anti-depressant,anti-emetic,and anti-bacterial.

2. Anti-tumorigenic activitiesHonokiol has shown pro-apoptotic effects in melanoma,sarcoma, myeloma, leukemia, bladder, lung, prostate, and colon cancer cell lines. Honokiol induces caspase-dependent apoptosis in a TRAIL-mediated manner, and potentiates the pro-apoptotic effects of doxorubicin and other etoposides. So potent is honokiol's pro-apoptotic effects that it overcomes even notoriously drug resistant neoplasms such as multiple myeloma and chronic B-cell leukemia.

3. Anti-thrombolyticHonokiol inhibits platelet aggregation in rabbits in a dose-dependent manner, and protects cultured RAEC against oxidized low density liproptein injury. Honokiol significantly increases the prostacyclin metabolite 6-keto-PGF1 alpha, potentially the key factor in honokiol’s anti-thrombotic activity.

4. Neurotrophic ActivityHonokiol has been shown to promote neurite outgrowth and have neuroprotective effects in rat cortical neurons. Additionally, honokiol increases free cytoplasmic Ca2+ in rat cortical neurons.


Storage   Store in cool, dry place and keep from direct light.

 

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